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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: KCNB1 All Species: 23.94
Human Site: T498 Identified Species: 75.24
UniProt: Q14721 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14721 NP_004966.1 858 95878 T498 T K R T L S E T S S S K S F E
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_543042 858 96045 T498 T K R T L S E T S S S K S F E
Cat Felis silvestris
Mouse Mus musculus Q03717 857 95674 T498 T K R A L S E T S S S K S F E
Rat Rattus norvegicus P15387 857 95619 T498 T K R A L S E T S S S K S F E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507252 997 108259 T436 A K R T L S E T S S S K S F E
Chicken Gallus gallus
Frog Xenopus laevis NP_001079257 876 99069 T498 K K R T L S E T S S N K S F D
Zebra Danio Brachydanio rerio XP_682848 827 92522 H472 G E R S Q D N H L S P S R W K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001195169 1105 121957 S585 H E R D R T Y S S T T Y T D H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 97.4 N.A. 93.4 94 N.A. 53.7 N.A. 75.5 66.6 N.A. N.A. N.A. N.A. 38.3
Protein Similarity: 100 N.A. N.A. 98.5 N.A. 96.3 96.1 N.A. 60.5 N.A. 85 77.3 N.A. N.A. N.A. N.A. 52.9
P-Site Identity: 100 N.A. N.A. 100 N.A. 93.3 93.3 N.A. 93.3 N.A. 80 13.3 N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 N.A. N.A. 100 N.A. 93.3 93.3 N.A. 93.3 N.A. 93.3 40 N.A. N.A. N.A. N.A. 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 13 0 0 25 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 13 0 13 0 0 0 0 0 0 0 13 13 % D
% Glu: 0 25 0 0 0 0 75 0 0 0 0 0 0 0 63 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 75 0 % F
% Gly: 13 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 13 0 0 0 0 0 0 13 0 0 0 0 0 0 13 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 13 75 0 0 0 0 0 0 0 0 0 75 0 0 13 % K
% Leu: 0 0 0 0 75 0 0 0 13 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 13 0 0 0 13 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 13 0 0 0 0 % P
% Gln: 0 0 0 0 13 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 100 0 13 0 0 0 0 0 0 0 13 0 0 % R
% Ser: 0 0 0 13 0 75 0 13 88 88 63 13 75 0 0 % S
% Thr: 50 0 0 50 0 13 0 75 0 13 13 0 13 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 13 0 % W
% Tyr: 0 0 0 0 0 0 13 0 0 0 0 13 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _